Targeted temperature,fluid overload limits,and neuromuscular control

This 2026 statement reconciles conflicting post-cardiac arrest trials (TTM-1 vs TTM-2) and extends targeted temperature control principles to traumatic brain injury and hypoxic-ischemic brain injury (HIBI).

The framework reinforces strict normothermia (36.5°C–37.5°C) as the non-negotiable minimum standard, while reserving moderate hypothermia (32°C–34°C) for refractory intracranial hypertension or severe cerebral edema. Active fever control using feedback-controlled cooling devices remains superior to passive cooling.

This trial protocol describes a two-arm cluster RCT in neonatal intensive care evaluating a structured, touch-based caregiver involvement model.

Because this publication is purely a study protocol, direct clinical outcomes remain unproven (CEBM Level 5). However, it highlights the growing emphasis on family-centered interventions in high-acuity environments.

A randomized controlled trial testing short VR sessions during work breaks against standard rest periods for adult ICU nurses.

The intervention group demonstrated significant reductions in Perceived Stress (PSS-10, p < 0.001), State Anxiety (STAI-S, p < 0.001), and Fatigue (FSS, p < 0.001) compared to controls.